Mathematical Modelling of Transcription Factors in Living Cells

or
How the mathematicians and the engineers meet the biologists

The subject of today involves a bit of my PhD's ideas and the one bit I am trying to work in at the moment (Although not too focused because I am doing the other bits too). I think generally speaking the title of this post sounds already a bit complicated but we are talking about PhD topics and subjects so there is no way to overcome complexity, the simple things are out there for everyone, the complex things are ignored by the most of you and deeply interesting to some of us. That’s not entirely my case though! I mean, I am slightly interested on them, but sometimes I just want to move over this and get a more simple life (I think I read it somewhere some time ago.. by that time I didnt quite understand it but every day that passes it sounds more and more familiar, so I already feel it too... it is unavoidable..) It appears that unless one is mental depressed and compromised he cannot enjoy this sort of life forever at least without questioning it (and I guess that may be part of the geniality of all this).
Ok, but regardless of my feelings I came out with this topic because I think it is interesting the way we can apply maths to explain how life works and on top of that there is not much being done in the area, just 2, maximum 3 groups in the world do something similar to this. Thought this is not my whole PhD, I couldnt just do that, but I will present a nice model (hopefully) and I think it will look pretty nice in my thesis..

Well I said hopefully because (maybe obviously) I still didnt solve the model but just some parcels, which is ok, nevertheless I need to solve the model.

Thats where I regret that my mathematics and physics knowledge is not very extensive so therefore I regret once again I didnt undertake the engineering degree :(
Some are medical frustrated, I am an engineer frustrated I am afraid... lol
On the plus side my boyfriend is an engineer and he is giving me a hand with the model, so thats where the biologist meet the engineers.. and this meeting is more than a meeting I hope, and it is genial ;)

So now I think with this precious help I am on the way to finish it and before I forgot I take the change to already acknowledge Pedro for his help ;) and once I finish this I will, I think, also publish something about it in a very practical and straightforward manner very different than what is in the literature I have been reading where one has to go through very complicated equations and protocols in order to maybe use a few of them applied to this sort of cases, it is not very clear how to do that and so on, basically I think the disciplines used to be too apart and they need to converge into a point, people need to work together!

Just to finish with my topic of today I leave a song that apparently represents me in a way, could be my song, it is one of many.. :)

Change everything you are
And everything you were
Your number has been called

Fights and battles have begun
Revenge will surely come
Your hard times are ahead

Best, you've got to be the best
You've got to change the world
And use this chance to be heard
Your time is now

Change everything you are
And everything you were
Your number has been called

Fights and battles have begun
Revenge will surely come
Your hard times are ahead

Best, you've got to be the best
You've got to change the world
And use this chance to be heard
Your time is now

Don’t let yourself down
And don’t let yourself go
Your last chance has arrived

Best, you've got to be the best
You've got to change the world
And use this chance to be heard
Your time is now

Pips go auctions?!

I have to share my experience of today's morning when me and Pedro decided to go to an auction here in Nottingham, but in the most dodgy area of Nottingham, by the way.. I havent been to an auction before, until today the closest thing to an auction I saw was the bids on ebay.. lolol so obviously I was not familiar with that at all, and thats why I probably went there, more in response to my curiosity than just to buy something. In fact I didnt spent a cent in there... but I am quite sure I could have done good business today, the offers are great, I should go back there with more time, like the whole day off!

Basically, after 10 minutes at Cripps health centre in the university, to take the stitches out of my forehead (consequence of my last trip to the snow), me and Pedro took a taxi to this place called John Pye Auctions in Radford. I got to know that through a friend that bought there a tv set some time ago but that place is apparently very popular, busy and known such that as soon as we got there it was full of people.

Before the auction starts people can look around the stocks. The reason why I went was to buy a tv, an LCD tv to put in our very nice living room. Basically we feel a bit poor with all the money we spent recently so any bargain is welcome! Nevertheless our budget was too low...

From the stocks we got interested in 7 or 8 LCDs. As soon as the auction started,
(late! I was really surprised!) we realized that we were surrounded by very strange people (actually I realized that as soon as we arrived but both of us just commented on that while sitting waiting for the bids to start). Mostly everyone was there purely for business reasons rather than buying for personal use, therefore everyone was very professional when bidding and we were like tw0 UFOs there..

And that was it, "our" LCDs were sold for about £200 and we didnt want to pay more than £100.. pity we still dont have the tv but I think we will just buy a new one sooner or later.

We keep the experience of being in an auction, real one, with that guy speaking out loud the prices and everyone seems to be hidden while bidding, I could actually hardly see who was bidding.. the gestures were too smooth.. like they were a bit embarrassed for being there! Like they felt they were committing a crime.. and there were those people on the phone, bidding for someone even more hidden... and there were those people that bought a lot of stuff, clearly they have a big business buying there to sell somewhere else..

Oh well, I should go back there one day, perhaps I could do a fortune out of it, but I am too afraid of high investment.. so back on my PhD life everything is calm and fine, I feel lazy today, I didnt want to come but ... thats life...
I feel I should get more fun :)

Snow trip part I

Hi everyone,

first of all my apologies for disappearing for such a long time, but first was the troubles with the moving into my new place together with the last days before going on holiday, you know to go on holiday means to leave a lot of work done and things organized such that my absence will not be that much noticed.. and that didnt give me time to post here and say goodbye before leaving on holiday. I didnt even told most of the people I know that I was going on holiday.. Anyway holiday was the main cause of my absence for such a long time. One of the most important things about this holiday was that it was my birthday present, a bit early but very convenient, my awesome great boyfriend offer me this lovely amazing time and I am really deeply thankful!

Picture of us as a tribute (I love you :))

DETAILS: The holiday was spent in France, in the Pyrenees, most precisely in Saint Lary soulain and it was awesome, as you might already be thinking I went skiing and I found it genial!! I am so sorry that just with 24 I found my favourite sportive activity and I am even more sorry that it is very restrictive, since, for obvious reasons it cannot be done in a regular basis.. Never mind, that musT be the reason why I liked it so much, you know, or you must know that I am not a sportive person at all, therefore this is my sport! Thrilling as I like (I love emotions and adrenaline, I am sort of addicted to it), and I love mountains therefore this combination could not be more perfect! It is awesome!

Map of my location:

Map of the trails

Click to enlarge

I called this post the part I because I am still missing the photos and the videos so I will come back to this topic soon, nevertheless I wanted to say hello to the readers and up date to the latest news :)

As I said this was my first time skiing ever so it was the real adventure, since standing up in the skis to come down the hill without falling over or crushing with other people everything was challenging! This sport demands a lot of energy, to be fit helps a lot and whether you did some skating in the past it also helps! I didnt have much problems learning how to ski, but I found myself very exhausted and I have a lot of muscle aches coming for muscles that I didnt even know they existed! In the end it appeared that I am apparently skilled for skiing, I managed to evolved quite fast, but I think that was probably because I was forced to go into the blue slopes before I even tasted the greens! After all I feel I am quite brave!

Unfortunately almost in the end I had a little accident that gave me a little trouble, basically cut my forehead by crushing with a friend (the story is a little bit more complicated, but I will detail it later one day)... I am good now, just a few stitches but its fine ;)

Little tip for skiing: I found that if I was listening to music while coming down the hill my performance was 10 times improved because I was feeling much more confident!

And there you go my favourite. That made part of my skiing soundtrack! It was so much fun!!!




And at last I am settling down in Nottingham, so it means parties are coming!! Get ready, I will announce soon :)))

One year of PhD life and a funny song

I did not have time to write this post yesterday but the 3rd of March deserves some attention and since my blog is somehow based on my PhD experience and life and could not forget this topic.

Indeed, yesterday I completed one year of PhD life. 365 days ago I moved from Portugal, most precisely from Almada to Nottingham to do a PhD in the University of Nottingham, School of Biomedical Sciences. Since then, a lot of things changed, I changed, but most of the things changed for better and I cannot deny I am very happy here and happy with my "job". Of course, as I am always complaining, this is not easy life but it has its rewards! I love science, I am passionate with discoveries and I like to work. Additionally, I have got a very nice life (dont get jealous ;)) ), now with my very nice new home, it is so comfortable and me and Pedro we are making it really nice and beautiful. I have holidays planned, I am going to skiing in two weeks, and I have got the perfect man, I am so happy :)))

Of course nothing is entirely perfect, I miss my parents and family and sometimes I feel really sad I cant hug them or my friends in Portugal, I miss our coffee times, our nights out, our funny moments or even the most serious ones..

But after all it seems that is being worth the effort!!


Not directly related to my sentimental-like post I leave this video below, just for fun and the sake of science showing that it can be funny too ;)



And thanks to Cati, that actually posted this video in the BCM communal blog: Sexy Hotte!

I am selling my bike, anyone interested?

Hey everyone,
I am now selling my bike since I just moved into my new place :))) yeahhh it happened, and I am so happy but I will come back to that topic in a dedicated post. Now I have some urgency to sell my bike, I dont need it anymore, where I live now I cant park it and ride it to the university so I want to sell it.

As you can figure from the picture it is a girls bike, purple. It will fit someone not very tall, 160-175 cm. It looks good, has minor scratches, breaks are good and has a code lock included.

I am selling it for £40. If you are interested or know someone who could be interested please ring 07515284479.




I will miss it, but new home, new life :)))